Matrix metalloproteinase-13 refines pathological staging of precancerous colorectal lesions
نویسندگان
چکیده
An exact classification of precancerous stages of colorectal polyps might improve therapy and patients´ outcome. Here we investigate the association between grade of dysplasia and Matrix metalloproteinase-13 (MMP-13) expression in 137 biopsies from patients with cancerous and non-cancerous colorectal adenomas. A reproducible staining procedure for histologic MMP-13 analysis in routinely fixed colorectal biopsy specimens has been established. A newly adopted immunoreactive scoring system for MMP-13 was demonstrated as reliable readout.The strength of the association between pathologic stage and immunoreactive MMP-13 scoring emphasizes its eligibility for diagnosis in precancerous colorectal lesions.
منابع مشابه
A Study of Matrix Metalloproteinase 9 and CD31 Expression through Immunohistochemistry in Invasive Breast Cancer
Background & Aims: This study was performed to investigate possible relationships between the manifestation of stromal cells (fibroblasts and/or myofibroblasts) by focusing on expression of their matrix metalloproteinase 9 (MMP9) and possible angiogenesis based on CD31 and CD34 antigen expression during the various steps of hyperplastic changes to precancerousstate and invasive breast cancer. M...
متن کاملTelomerase activity in preneoplastic and neoplastic gastric and colorectal lesions.
Recent evidence indicates that telomerase activity may be necessary for cell immortality, which is required for the sustained and indefinite growth of most malignant cells. We analyzed telomerase activity in gastric and colorectal cancers and in gastric and colorectal precancerous lesions to determine whether malignant progression depends on the activation of telomerase and at what stage of car...
متن کاملPTEN expression profiles in colorectal adenocarcinoma and its precancerous lesions.
The aim of the study was to determine expression of the PTEN suppressor gene in colorectal adenocarcinoma and its precancerous lesions (adenomatous polyps) in correlation with common clinical and histopathological features. Forty-four patients with adenomatous polyps and 32 with primary adenocarcinoma of the colon or rectum were enrolled in the study. They underwent endoscopic removal of polyps...
متن کاملTIMP-1: a strong player in colorectal cancer.
In t h i s i s su e of t he J Gastrointestin Liver Dis, Ionescu et al evaluate, in a pilot study, the potential prognostic impact of a panel of six genes (CDH1, SMAD3, TGFβ1, ICAM-1, TIMP1 and MUC12) in colorectal cancer (CRC) patients [1]. ese genes have been studied by RT-qPCR in normal and CRC tumor tissues, and the relative gene expression values have been correlated with clinical, histolog...
متن کاملExpression of matrix metalloproteinase-7 correlates with the invasion of T1 colorectal carcinoma
T1 colorectal carcinomas (CRCs) are an initial site of metastatic spread. Various risk factors for lymph node metastasis have been investigated in T1 CRCs. However, the major step in the entire process of metastasis remains unclear. In terms of carcinoma invasion and metastasis, matrix metalloproteinases (MMPs) have recently gained increasing attention. Notably, MMP-7 is frequently overexpresse...
متن کامل